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- Title
Intermuscular coherence as an early biomarker for amyotrophic lateral sclerosis: The protocol for a prospective, multicenter study.
- Authors
Issa, Naoum P.; Aydin, Serdar; Polley, Eric; Carberry, Nathan; Garret, Mark A.; Smith, Sean; Habib, Ali A.; Baumgartner, Nicholas W.; Soliven, Betty; Rezania, Kourosh
- Abstract
Objective: To describe the protocol of a prospective study to test the validity of intermuscular coherence (IMC) as a diagnostic tool and biomarker of upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Methods: This is a multicenter, prospective study. IMC of muscle pairs in the upper and lower limbs is gathered in ∼650 subjects across three groups using surface electrodes and conventional electromyography (EMG) machines. The following subjects will be tested: 1) neurotypical controls; 2) patients with symptomatology suggestive for early ALS but not meeting probable or definite ALS by Awaji Criteria; 3) patients with a known ALS mimic. The recruitment period is between 3/31/2021 and 12/31/2025. Written consent will be sought from the subject or the subject's legally authorized representative during enrollment. Results: The endpoints of this study include: 1) whether adding IMC to the Awaji ALS criteria improve its sensitivity in early ALS and can allow for diagnosis earlier; 2) constructing a database of IMC across different ages, genders, and ethnicities. Significance: This study may validate a new inexpensive, painless, and widely available tool for the diagnosis of ALS.
- Subjects
AMYOTROPHIC lateral sclerosis; MOTOR neuron diseases; TRAPEZIUS muscle; BIOMARKERS; NEURODEGENERATION; MOTOR neurons; TEST validity
- Publication
PLoS ONE, 2024, Vol 19, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0303053