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- Title
DEVELOPMENT AND EVALUATION OF THE SINOMENINE TRANSDERMAL PATCH.
- Authors
Jianping Wang; Jinlan Ruan; Changgong Zhang; Yujie Ye; Yaling Cai; Yunxia Wu
- Abstract
Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.
- Subjects
TRANSDERMAL medication; HIGH performance liquid chromatography; ADHESION; FORMALDEHYDE; CHEMICAL peel; STEEL; ERYTHEMA; EDEMA; MICE
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2008, Vol 21, Issue 4, p407
- ISSN
1011-601X
- Publication type
Article