We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
AAZTA: An Ideal Chelating Agent for the Development of <sup>44</sup>Sc PET Imaging Agents.
- Authors
Nagy, Gábor; Szikra, Dezső; Trencsényi, György; Fekete, Anikó; Garai, Ildikó; Giani, Arianna M.; Negri, Roberto; Masciocchi, Norberto; Maiocchi, Alessandro; Uggeri, Fulvio; Tóth, Imre; Aime, Silvio; Giovenzana, Giovanni B.; Baranyai, Zsolt
- Abstract
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44Sc(AAZTA)− chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
- Subjects
SCANDIUM isotopes; CHELATING agents; POSITRON emission tomography; ROBUST control; BIOMOLECULES; RADIOPHARMACEUTICALS
- Publication
Angewandte Chemie International Edition, 2017, Vol 56, Issue 8, p2118
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201611207