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- Title
Anti-endomysium and anti-gliadin antibodies as serological markers for coeliac disease in childhood: a clinical study to develop a practical routine.
- Authors
Grodzinsky, E; Jansson, G; Skogh, T; Stenhammar, L; Falth-Magnusson, K; Fälth-Magnusson, K
- Abstract
Anti-gliadin and anti-endomysium antibodies were analyzed in 174 children with suspected or verified coeliac disease with the aim of developing a practical routine. The biopsy was performed without knowledge of the antibody levels. To screen for coeliac disease is children younger than 2 years, we suggest the use of IgA anti-gliadin antibodies, giving a sensitivity of 100% and a specificity of 86%. In older children both tests should be used in parallel, i.e. a biopsy should be performed if at least one of the tests is positive, giving a sensitivity of 98% and a specificity of 81%. To avoid unnecessary biopsy before mucosal relapse can be demonstrated during gluten challenge in a child without clinical symptoms, we suggest that the tests are used as serial testing, i.e. a biopsy should be performed if both tests are positive.
- Publication
Acta Paediatrica, 1995, Vol 84, Issue 3, p294
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/j.1651-2227.1995.tb13631.x