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- Title
Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona.
- Authors
Kang, Biao; Schöttler, Susanne; Winzen, Svenja; Mohr, Kristin; Landfester, Katharina; Wurm, Frederik R.; Okwieka, Patricia; Mailänder, Volker; Langhanki, Jens; Opatz, Till
- Abstract
Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then studied. Low overall protein adsorption with a distinct protein pattern and high specific affinity for DC binding were observed, thus indicating an efficient combination of 'stealth' and targeting behavior.
- Subjects
NANOCARRIERS; NANOMEDICAL research; BLOOD proteins; POLYETHYLENE glycol; HYDROPHOBIC interactions; ISOTHERMAL titration calorimetry; HYDROXYETHYL starch; NANOCAPSULES
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 25, p7436
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201502398