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- Title
LIVER FIBROSIS PROTECTIVE EFFECT OF HOVENIA DULCIS FRUIT.
- Authors
Lee, J. J.; Yang, S. Y.; Kim, D. H.; Hur, S. J.; Lee, J. D.; Yum, M. J.; Song, M. D.
- Abstract
This study was conducted to investigate the effects of the fruit extract from Hovenia dulcis (HD) on liver fibrosis in rats. In these experiments, liver fibrosis was induced by carbon tetrachloride (CCl4) treatment. Forty rats were randomly divided into four groups: Normal group (corn oil subcutaneous injection), CCl 4 group (CCl4-induced liver fibrosis group; 50% CCl4, 1.0 mL/kg), Normal + HD group (20% HD, 4.0 mL/kg), CCl4 + HD group (20% HD, 4.0 mL/kg). To study the effect of extracts from HD fruit on the liver fibrosis in rats, which was induced by CCl4, enzyme activities such as Alanine aminotranferase (ALT) and Aspartate aminotransferase (AST) were measured in the serum. Bilirubin concentration in the serum and expression of collagen I and III in liver tissue were also analyzed. In addition the pathology of the liver tissue was evaluated. Tetrazolium- based colorimetric (MTT) and Sulforhodamin B (SRB) were used to analyze the effect of treatment on hepatic stellate cell (HSC) proliferation. In the present study, the ALT, AST and Bilirubin levels and expression volume of collagen I and III in the CCl4 + HD group were found to be lower than in the CCl4 group. In addition, HD treatment reduced the accumulation of collagen in liver tissue and inhibited HSC proliferation. These results indicated that the extracts from HD fruit may inhibit liver fibrosis and thus could be used as a therapeutic agent to prevent liver fibrosis.
- Subjects
FIBROSIS; HOVENIA dulcis; THERAPEUTIC use of plant extracts; LABORATORY rats; ASPARTATE aminotransferase; BILIRUBIN; KUPFFER cells; PREVENTION
- Publication
Current Topics in Nutraceutical Research, 2014, Vol 12, Issue 1/2, p43
- ISSN
1540-7535
- Publication type
Article