We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Irradiation of primary thalamic and brainstem tumors in a pediatric population. A 33-year experience.
- Authors
Grigsby, Perry W.; Thomas, Patrick R. M.; Schwartz, Henry G.; Fineberg, Barbara; Grigsby, P W; Thomas, P R; Schwartz, H G; Fineberg, B
- Abstract
A retrospective analysis of 70 pediatric patients (less than 16 years of age) with histologically proven or presumed primary neoplasms of the thalamus, hypothalamus, and brainstem, treated with combined surgery and postoperative radiotherapy or radiotherapy alone at the Washington University Medical Center from January 1950 through December 1983, is reported. Overall survival for all patients at 5 and 10 years was 34.9% and 32.7%, respectively. Follow-up of the 22 surviving patients ranged from 3.0 to 20.0 years (median, 10.6 years). Statistical analysis of multiple prognostic factors was performed. Prognostic factors found by single variate analysis to significantly influence survival were primary site of disease, extent of surgery, race, cranial nerve paresis at diagnosis, and dose of radiation. Factors evaluated but found to be insignificant were age at diagnosis, duration of symptoms before diagnosis, sex, and volume irradiated. Multivariate analysis revealed that only total radiation dose and race were of prognostic significance.
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 12, p2901
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19871215)60:12<2901::AID-CNCR2820601210>3.0.CO;2-W