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- Title
A primary lung carcinoma producing alpha-fetoprotein, carcinoembryonic antigen, and human chorionic gonadotropin. Immunohistochemical and biochemical studies.
- Authors
Yoshimoto, Tomohiro; Higashino, Kazuya; Hada, Toshikazu; Tamura, Shinsuke; Nakanishi, Kenji; Mitsunobu, Masao; Uematsu, Kunio; Matsuoka, Takamasa; Taketa, Kazuhisa; Yoshimoto, T; Higashino, K; Hada, T; Tamura, S; Nakanishi, K; Mitsunobu, M; Uematsu, K; Matsuoka, T; Taketa, K
- Abstract
This article documents a patient with lung carcinoma that produced three oncofetal antigens including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and human chorionic gonadotropin (hCG). Serum AFP, CEA, and hCG-beta-subunit were extremely high--118,000 ng/ml, 133 ng/ml and 0.9 ng/ml, respectively. Immunohistochemical staining of these tumor markers revealed that these proteins were present in different cells. The pattern of lectin affinity electrophoresis of AFP resembled that of hepatocellular carcinoma. Also investigated was the reactivity of serum CEA to monoclonal antibodies against peptide or sugar moieties. Serum CEA values measured by antipeptide monoclonal antibodies were higher than those measured by antisugar monoclonal antibodies. The demonstration of AFP, CEA, and hCG in different tumor cells suggests that three genomes were not reactivated together in a cell, and the lung carcinoma probably consisted of at least three clones of cancer cells with different phenotypes.
- Subjects
ALPHA fetoproteins; CANCER; CHORIONIC gonadotropins; CYTOCHEMISTRY; ELECTROPHORESIS; IMMUNOENZYME technique; LUNG tumors; MONOCLONAL antibodies; PLANT proteins; TUMOR antigens
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 11, p2744
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19871201)60:11<2744::AID-CNCR2820601126>3.0.CO;2-H