We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clonogenic assay and in vitro chemosensitivity testing of human urologic malignancies.
- Authors
Sarosdy, Michael F.; Lamm, Donald L.; Radwin, Howard M.; Von Hoff, Daniel D.; Sarosdy, M F; Lamm, D L; Radwin, H M; Von Hoff, D D
- Abstract
Over the past year, we have attempted to grow both primary and metastatic urologic malignancies using a recently developed human tumor cloning system. Formation of colonies in vitro occurred in 125 of 164 primary tumors (76%), including 34 of 47 uroepithelial cancer specimens, 45 of 50 renal cell cancer specimens, 24 of 33 prostatic cancer specimens, and 22 of 34 testicular cancer specimens. A large percentage of metastatic cancers have also been successfully cultured. Growth sufficient for chemosensitivity testing ranged from 43% of the uroepithelial cancers cultured to 64% of the renal cell cancer specimens cultured. When in vitro chemosensitivity testing was performed, the in vitro chemosensitivity results show a striking similarity to clinical response rates for the same agents used for these tumors. Overall the human tumor cloning system appears to be a reasonable model for the study of human urologic malignancies.
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 7, p1332
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821001)50:7<1332::AID-CNCR2820500719>3.0.CO;2-8