We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy.
- Authors
Rideout, Todd C.; Harding, Scott V.; Mackay, Dylan S.
- Abstract
Reducing intestinal cholesterol absorption with plant sterol consumption is a well-characterized strategy to lower LDL-C and potentially reduce cardiovascular disease risk. However, over 50 years of clinical research demonstrate that there is significant heterogeneity in the individual LDL-C lowering response to plant sterol therapy. A clear understanding of why plant sterols work effectively in some individuals but not in others will ensure optimal integration of plant sterols in future personalized nutritional lipid-lowering strategies. This review will examine the current knowledge base surrounding the metabolic and genetic determinants of LDL-C lowering in response to plant sterol consumption.
- Subjects
LOW density lipoproteins; METABOLISM; STEROLS; CHOLESTEROL; HUMAN genetic variation; HETEROGENEITY; CARDIOVASCULAR diseases
- Publication
Canadian Journal of Physiology & Pharmacology, 2012, Vol 90, Issue 5, p509
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/y2012-060