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- Title
Antileukoprotease in Psoriatic Scales.
- Authors
Wiedow, Oliver; Young, Janice A.; Davison, Matthew D.; Christophers, Enno
- Abstract
Antileukoprotease is known to be an antiproteolytic compound of mucous secretions in humans. While searching for peptide-like inhibitors of neutrophil-derived serine proteases in horny layers of human skin, we isolated a potent inhibitor of human leukocyte elastase (EC 3.4.21.37) and cathepsin G (EC 3.4.21.20) from psoriatic scales. This inhibitor showed inhibitory constants for human leukocyte elastase of approximately 0.5-2 × 10-10 M and for cathepsin G of 2-4 × 10-9N. The N-terminal amino acid sequence of the purified peptide matched the sequence of antileukoprotease and both peptides showed the same Mr on SDS-PAGE. Therefore, antileukoprotease may not only regulate serine protease activities in mucous secretions, but also in skin.
- Subjects
PROTEOLYTIC enzymes; LEUCOCYTE elastase; PSORIASIS; AMINO acids; PEPTIDES; SKIN
- Publication
Journal of Investigative Dermatology, 1993, Vol 101, Issue 3, p305
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12365430