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- Title
Longwave Ultraviolet Radiation (UVA, 320-400 nm)- Induced Tan Protects Human Skin Against Further UVA Injury.
- Authors
Margolis, Randall J.; Sherwood, Margaret; Maytum, Dan J.; Granstein, Richard D.; Weinstock, Martin A.; Parrish, John A.; Gange, Richard W.
- Abstract
The protective effect of a UVA (320-400 nm) induced tan against cutaneous injury by further UVA-irradiation was studied by evaluating the histopathologic changes in tanned and untanned normal human buttock skin 24 h after exposure to 2 and 4 minimal erythema doses of UVA. In each subject there were fewer polymorphonuclear leukocytes and less endothelial cell prominence and vessel wall necrosis in the UVA tanned control and tanned UVA-irradiated skin there was a prominent mononuclear cell inflammatory infiltrate that was much greater than in untanned skin. In immunoperoxidase stained tissue sections, the mononuclear cells were predominantly T cells, and in all of the specimens the number of phenotypic helper/inducer cells exceeded the phenotypic cytotoxic/suppressor cells. This demonstrates that a UVA tan provides photoprotection against acute UVA exposure. In addition, tanning, with or without further UVA-irradiation, was associated with a mononuclear cell inflammatory infiltrate.
- Subjects
IRRADIATION; ULTRAVIOLET radiation; RADIATION; SUNTAN; LEUCOCYTES; NEUTROPHILS; NECROSIS; SUPPRESSOR cells
- Publication
Journal of Investigative Dermatology, 1989, Vol 93, Issue 6, p713
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12284390