We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Helicobacter pylori vacA Arrangement and Related Diseases: A Retrospective Study Over a Period of 15 Years.
- Authors
Vincenzo De Francesco; Marcella Margiotta; Angelo Zullo; Cesare Hassan; Floriana Giorgio; Mariangela Zotti; Giuseppe Stoppino; Alessia Bastianelli; Francesco Diterlizzi; Giovanna Verderosa; Sergio Morini; Carmine Panella; Enzo Ierardi
- Abstract
Abstract Peptic ulcer disease incidence is decreasing. Both s1m1 and s1m2 vacA gene combinations of Helicobacter pylori have been associated with the development of major gastroduodenal diseases. This study assessed whether H. pylori vacA gene arrangement changed over 15 years in a Southern Italy area. H. pylori-positive patients observed in January–June 1989 and January–June 2005 were selected. Histological specimens were retrieved to extract DNA for vacA arrangement characterization (mid-m and peptide signal-s regions) by using the polymerase chain reaction. Fifty-nine patients in the first period and 56 matched patients in the second period were evaluated. A correlation between s1 presence and intestinal metaplasia at histology was found. Overall, the s1m1 combination increased (P P P P P P H. pylori strains contrasts with peptic ulcer incidence reduction.
- Subjects
SOUTHERN Italy; HELICOBACTER pylori; PEPTIC ulcer; GASTRIC diseases; METAPLASIA; MEDICAL care research; DISEASE incidence; VIRAL genetics
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 1, p97
- ISSN
0163-2116
- Publication type
Article