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- Title
High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels.
- Authors
Helle, F.; Karlsen, T. V.; Tenstad, O.; Titze, J.; Wiig, H.
- Abstract
Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major resistance vessel of rat skin, the pre-capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m ( P < 0.01). Pre-capillary arterioles from muscle displayed similar contractions to ANG II, independent of the diet. As ANG II and the renin-angiotensin system are strongly involved in salt conservation, we explored whether vasoreactivity for noradrenaline was increased as well, because this is a functionally unrelated hormone. At low doses, contractions were similar, but at 10−5 and 10−4 m, noradrenaline produced stronger contractions in skin vessels from high-salt compared with low-salt rats ( P < 0.01). Conclusions Our data demonstrate significantly increased hormonal vasoreactivity of skin vessels from rats on a high-salt diet, which could increase peripheral resistance in many situations and contribute to higher pressure in salt-sensitive hypertension. As vessels from adjacent muscle were unaffected, we raise the interesting possibility that increased vasoreactivity in the skin could be linked to osmotically inactive Na+ accumulation.
- Subjects
HIGH-salt diet; HORMONES; NORADRENALINE; ANGIOTENSIN II; AGAROSE; SKIN blood-vessels; HOMEOSTASIS
- Publication
Acta Physiologica, 2013, Vol 207, Issue 3, p577
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/apha.12049