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- Title
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
- Authors
Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F.; Blondal, Thorarinn; Gylfason, Arnaldur; Agnarsson, Bjarni A.; Benediktsdottir, Kristrun R.; Magnusdottir, Droplaug N.; Orlygsdottir, Gudbjorg; Jakobsdottir, Margret; Stacey, Simon N.; Sigurdsson, Asgeir; Wahlfors, Tiina; Tammela, Teuvo; Breyer, Joan P.; McReynolds, Kate M.; Bradley, Kevin M.; Saez, Berta; Godino, Javier; Navarrete, Sebastian
- Abstract
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 10−10) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 10−15) and rs445114[T] (OR = 1.14, P = 4.7 × 10−10), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 10−11) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 10−12). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
- Subjects
GENETIC research; MULTIVARIATE analysis; PROSTATE cancer; CANCER susceptibility; GENOMES
- Publication
Nature Genetics, 2009, Vol 41, Issue 10, p1122
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.448