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- Title
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density.
- Authors
Thorleifsson, Gudmar; Holm, Hilma; Edvardsson, Vidar; Walters, G. Bragi; Styrkarsdottir, Unnur; Gudbjartsson, Daniel F.; Sulem, Patrick; Halldorsson, Bjarni V.; de Vegt, Femmie; d'Ancona, Frank C. H.; den Heijer, Martin; Franzson, Leifur; Christiansen, Claus; Alexandersen, Peter; Rafnar, Thorunn; Kristjansson, Kristleifur; Sigurdsson, Gunnar; Kiemeney, Lambertus A.; Bodvarsson, Magnus; Indridason, Olafur S.
- Abstract
Kidney stone disease is a common condition. To search for sequence variants conferring risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and 42,510 controls from Iceland and The Netherlands. We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 × 10−12 for rs219780[C]). Approximately 62% of the general population is homozygous for rs219780[C] and is estimated to have 1.64 times greater risk of developing the disease compared to noncarriers. The CLDN14 gene is expressed in the kidney and regulates paracellular permeability at epithelial tight junctions. The same variants were also found to associate with reduced bone mineral density at the hip (P = 0.00039) and spine (P = 0.0077).
- Subjects
ICELAND; NETHERLANDS; KIDNEY diseases; KIDNEY stones; EPITHELIAL cells; GENOMES; CLINICAL trials
- Publication
Nature Genetics, 2009, Vol 41, Issue 8, p926
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.404