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- Title
The Effect of Anti-Oestrogens on Cytokine Production In Vitro.
- Authors
Järvinen, L. S.; Pyrhönen, S.; Kairemo, K. J. A.; Paavonen, T.
- Abstract
Oestrogens can regulate immune functions, and due to this females have more effective immune responses than males. Oestrogens and anti-oestrogens enhance T-cell-dependent antibody production of B cells <em>in vitro</em>. The cytokine mediators which are behind oestrogen and anti-oestrogen induced effects are not yet known. The authors studied whether anti-oestrogens (tamoxifen and toremifene) can regulate PMA-induced cytokine production of B-, T- or myeloid cell lines. Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1β, IL-6 and IFN-γ production and toremifene inhibited it. Anti-oestrogens did not have any significant effect on cytokine production of myeloid cells.
- Subjects
ESTROGEN; IMMUNE response; T cells; IMMUNOGLOBULINS; B cells
- Publication
Scandinavian Journal of Immunology, 1996, Vol 44, Issue 1, p15
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-85.x