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- Title
Loss of HLA Heavy Chain and β2-Microglobulin in HLA Negative Tumours.
- Authors
Cabrera, T.; Concha, A.; Ruiz-Cabello, F.; Garrido, F.
- Abstract
Expression of HLA class I antigens on the cell surface requires the association of heavy chain. endogenous peptide and β-microglobulin (β2m). We have studied the expression of free class I heavy chain and β2m in cryostatic sections of 51 HLA class I negative human tumours of different origin. Selective low expression of β2m was observed only on the 9 colorectal adenocarcinomas. In contrast, simultaneous under-expression of heavy chain and β2m was detected in the rest of the tumours studied. Our results suggest that the accumulation in the cytoplasm of HLA heavy chain in HLA negative colorectal careinomas is a particular mechanism that cannot be applied to all HLA negative tumours.
- Subjects
ANTIGENS; IMMUNITY; IMMUNOGLOBULINS; CELL membranes; ADENOCARCINOMA; CYTOPLASM
- Publication
Scandinavian Journal of Immunology, 1991, Vol 34, Issue 2, p147
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01531.x