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- Title
Sustainable and Safe N -alkylation of N -heterocycles by Propylene Carbonate under Neat Reaction Conditions.
- Authors
Czompa, Andrea; Bogdán, Dóra; Balogh, Balázs; Erdei, Eszter; Selymes, Patrik; Csomos, Attila; Mándity, István M.
- Abstract
A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform N-alkylation of N-, O- and/or S-containing heterocyclic compounds. PC in these reactions served as both the reagent and solvent. Importantly, no genotoxic alkyl halides were required. No auxiliary was necessary when using anhydrous PC. Product formation includes nucleophilic substitution with the concomitant loss of water and carbon dioxide. Substrates prepared, including the newly invented PROTAC drugs, are widely used.
- Subjects
PROPYLENE carbonate; CARBON dioxide in water; HALOALKANES; ALKYLATION; HETEROCYCLIC compounds
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 10, p5523
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25105523