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- Title
Anastasis: cell recovery mechanisms and potential role in cancer.
- Authors
Mohammed, Rebar N.; Khosravi, Mohsen; Rahman, Heshu Sulaiman; Adili, Ali; Kamali, Navid; Soloshenkov, Pavel Petrovich; Thangavelu, Lakshmi; Saeedi, Hossein; Shomali, Navid; Tamjidifar, Rozita; Isazadeh, Alireza; Aslaminabad, Ramin; Akbari, Morteza
- Abstract
Balanced cell death and survival are among the most important cell development and homeostasis pathways that can play a critical role in the onset or progress of malignancy steps. Anastasis is a natural cell recovery pathway that rescues cells after removing the apoptosis-inducing agent or brink of death. The cells recuperate and recover to an active and stable state. So far, minimal knowledge is available about the molecular mechanisms of anastasis. Still, several involved pathways have been explained: recovery through mitochondrial outer membrane permeabilization, caspase cascade arrest, repairing DNA damage, apoptotic bodies formation, and phosphatidylserine. Anastasis can facilitate the survival of damaged or tumor cells, promote malignancy, and increase drug resistance and metastasis. Here, we noted recently known mechanisms of the anastasis process and underlying molecular mechanisms. Additionally, we summarize the consequences of anastatic mechanisms in the initiation and progress of malignancy, cancer cell metastasis, and drug resistance. AevQPWy5vdjWoq6m9WXWU6 Video Abstract
- Subjects
APOPTOTIC bodies; DNA repair; DRUG resistance; MITOCHONDRIAL membranes; PHOSPHATIDYLSERINES; CELL death
- Publication
Cell Communication & Signaling, 2022, Vol 20, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-022-00880-w