We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acetylcholinesterase activity in the rat brain after pneumococcal meningitis.
- Authors
Barichello, Tatiana; Generoso, Jaqueline S.; Collodel, Allan; Moreira, Ana Paula; Michelon, Cleonice M.; Raupp, Alice; Cipriano, Andreza L.; Fraga, Daiane de Bittencourt; Zugno, Alexandra I.
- Abstract
ABSTRACT Pneumococcal meningitis is a life-threatening disease characterized by acute purulent infection of the meninges causing neuronal injury, cortical necrosis and hippocampal apoptosis. Cholinergic neurons and their projections are extensively distributed throughout the central nervous system. The aim of this study was to assess acetylcholinesterase activity in the rat brain after pneumococcal meningitis. In the hippocampus, frontal cortex and cerebrospinal fluid, acetylcholinesterase activity was found to be increased at 6, 12, 24, 48 and 96 hr without antibiotic treatment, and at 48 and 96 hr with antibiotic treatment. Our data suggest that acetylcholinesterase activity could be related to neuronal damage induced by pneumococcal meningitis.
- Subjects
ACETYLCHOLINESTERASE; PNEUMOCOCCAL meningitis; HIPPOCAMPUS (Brain); APOPTOSIS; CENTRAL nervous system; CEREBROSPINAL fluid; LABORATORY rats
- Publication
Microbiology & Immunology, 2012, Vol 56, Issue 3, p191
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2011.00418.x