We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of the Aβ Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma.
- Authors
Salt, T.; Nizari, S.; Cordeiro, M.; Russ, H.; Danysz, W.
- Abstract
Several lines of evidence suggest that there are similarities in the pathomechanisms of glaucoma and Alzheimer's disease, and that amyloid-beta (Aβ) could be a new, promising target for neuroprotective therapy of glaucoma. In the present study, we evaluated the effect of the Aβ aggregation modulator MRZ-99030 in the Morrison model of glaucoma based on increased intraocular pressure (IOP) in rats. MRZ-99030 provided dose-dependent neuroprotection and at the highest dose (240 mg/kg) reduced the degree of RGC apoptosis to 33 % of that seen after vehicle ( P < 0.05; one-way ANOVA). No significant effect on IOP was observed. Pharmacokinetic experiments showed that following systemic injection of MRZ-99030, concentrations above affinity for Aβ were reached. Hence the present results are consistent with the notion that Aβ is a promising target for neuroprotective intervention in glaucoma and that MRZ-99030 may be a good drug candidate for further development.
- Subjects
GLAUCOMA; ALZHEIMER'S disease prevention; IMMUNOMODULATORS; RETINAL degeneration; AMYLOID beta-protein; NEUROPROTECTIVE agents; INTRAOCULAR pressure; PREVENTION
- Publication
Neurotoxicity Research, 2014, Vol 26, Issue 4, p440
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-014-9488-6