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- Title
Primary Bilateral Intraosseous Rosai-Dorfman Disease.
- Authors
Foster, Charlotte R.; Reith, John D.; Habeeb, Omar
- Abstract
Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disease of unknown etiology. Typically presenting with cervical adenopathy and constitutional symptoms, RDD involves bone in less than 10% of cases—and rarely presents as a primary intraosseous lesion. In this report, we describe the presentation of primary, bilateral intraosseous RDD, the first known case in the literature. Asymmetrically involving the lateral femoral condyles of a 59-year-old male, the lesion was discovered incidentally during evaluation and workup for giant cell tumor of bone involving the left tibia. Confirmation of the diagnosis required multiple biopsies and extensive evaluation—reflecting the diagnostic challenge associated with this case. We discuss the clinical, radiological, and pathological findings that allowed us to establish the diagnosis—as well as key differential diagnostic considerations and clinical outcome to date.
- Subjects
NON-langerhans-cell histiocytosis; GIANT cell tumors; ETIOLOGY of diseases
- Publication
International Journal of Surgical Pathology, 2023, Vol 31, Issue 7, p1347
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969221142042