We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relapse after severe acute malnutrition: A systematic literature review and secondary data analysis.
- Authors
Stobaugh, Heather C.; Mayberry, Amy; Lelijveld, Natasha; McGrath, Marie; Bahwere, Paluku; Zagre, Noël Marie; Manary, Mark J.; Black, Robert
- Abstract
The objectives of most treatment programs for severe acute malnutrition (SAM) in children focus on initial recovery only, leaving post‐discharge outcomes, such as relapse, poorly understood and undefined. This study aimed to systematically review current literature and conduct secondary data analyses of studies that captured relapse rates, up to 18‐month post‐discharge, in children following recovery from SAM treatment. The literature search (including PubMed and Google Scholar) built upon two recent reviews to identify a variety of up‐to‐date published studies and grey literature. This search yielded 26 articles and programme reports that provided information on relapse. The proportion of children who relapsed after SAM treatment varied greatly from 0% to 37% across varying lengths of time following discharge. The lack of a standard definition of relapse limited comparability even among the few studies that have quantified post‐discharge relapse. Inconsistent treatment protocols and poor adherence to protocols likely add to the wide range of relapse reported. Secondary analysis of a database from Malawi found no significant association between potential individual risk factors at admission and discharge, except being an orphan, which resulted in five times greater odds of relapse at 6 months post‐discharge (95% CI [1.7, 12.4], P = 0.003). The development of a standard definition of relapse is needed for programme implementers and researchers. This will allow for assessment of programme quality regarding sustained recovery and better understanding of the contribution of relapse to local and global burden of SAM.
- Subjects
MALNUTRITION treatment; ANTHROPOMETRY; COMMUNITY health services; MEDLINE; ONLINE information services; PATIENT compliance; RESEARCH funding; TIME; SYSTEMATIC reviews; DISEASE relapse; SECONDARY analysis; DISCHARGE planning; TREATMENT effectiveness; SEVERITY of illness index; WASTING syndrome; DESCRIPTIVE statistics; ODDS ratio; CHILDREN
- Publication
Maternal & Child Nutrition, 2019, Vol 15, Issue 2, pN.PAG
- ISSN
1740-8695
- Publication type
Article
- DOI
10.1111/mcn.12702