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- Title
Doppelinfektion mit Hepatitis B und C. Spontanverlauf und Ansprechen auf virostatische Therapie bei Kindern nach onkologischen Erkrankungen.
- Authors
Moser, Andrea; Lackner, Herwig; Deutsch, Johann; Kerbl, Reinhold; Schwinger, Wolfgang; Dornbusch, Hans Jürgen; Kessler, Harald H.; Urban, Christian
- Abstract
Combined chronic hepatitis B and C is a long-term complication in children surviving malignancy. We report on seven children who acquired hepatitits B as well as C virus infection during treatment for different malignancies. Four patients showed a spontaneous HBe Ag/anti-HBe seroconversion, two patients spontaneous clearance of hepatitis C virus, and one patient showed both HBe Ag/anti-HBe seroconversion and clearance of hepatitis C virus. One patient developed HBe Ag/anti- HBe seroconversion after antiviral interferon monotherapy and another patient after combination therapy with interferon/famcyclovir. Three patients developed complete sustained response of hepatitis C to a combined virostatic therapy with interferon and ribavirin. A total of 4 of 7 patients had a clearance of both infections and 3 of 7 patients had a clearance of at least one infection. Conclusion: Our data in long-term survivors of childhood cancer with combined hepatitis B and C showed a remarkably high rate of spontaneous cure and a favourable response to antiviral therapy.
- Subjects
HEPATITIS B; CANCER; ANTINEOPLASTIC agents; HEPATITIS C virus; BLOOD plasma; VIRUS diseases; THERAPEUTICS
- Publication
Wiener Klinische Wochenschrift, 2003, Vol 115, Issue 1/2, p66
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/BF03040276