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- Title
Biosynthesis of Antitumoral and Bactericidal Sanguinarine.
- Authors
García, Víctor P.; Valdés, F.; Martín, R.; Luis, J. C.; Afonso, A. M.; Ayala, J. H.
- Abstract
A simple, rapid, and reliable TLC method for the separation and determination of sanguinarine has been established. This intensively studied biologically active alkaloid has a wide range of potentially useful medicinal properties, such as antimicrobial, antiinflammatory, and antitumoral activities. Sanguinarine has also been incorporated into expectorant mixtures and has a strong bactericidal effect upon gram-positive bacteria, particularly Bacillus anthracis and staphylococci. These medicinal properties are due to the interaction of sanguinarine with DNA. A fibre-optic-based fluorescence instrument for in situ scanning was used for quantitative measurements. The sanguinarine was determined over the range 5-40 ng and a detection limit of 1.60 ng. The method was applied to the quantification of sanguinarine in tissue culture extracts of Chelidonium majus L.
- Subjects
BIOSYNTHESIS; ALKALOIDS; ANTI-infective agents; ANTI-inflammatory agents; BACILLUS anthracis; STAPHYLOCOCCUS; CHELIDONIUM
- Publication
Journal of Biomedicine & Biotechnology, 2006, p1
- ISSN
1110-7243
- Publication type
Article
- DOI
10.1155/JBB/2006/63518