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- Title
Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels.
- Authors
Okenov, A. O.; Iaparov, B. I.; Moskvin, A. S.
- Abstract
Six thermo-activated transient receptor potential (TRP) channels are the molecular basis of the thermosensation for mammals. However, the molecular source of their gating remains unknown. In the Letter, we suggest a physically based model for the TRP channels and show that the temperature dependence of the "internal friction" can be a key factor governing the ion channels gating. Results of the computer modeling allowed us to successfully reproduce the experimental data for the open probability Popen of the TRPV1 and TRPM8 channels at different temperatures and voltages.
- Subjects
TRP channels; ION channels; COMPUTER simulation; TRPV cation channels; INTERNAL friction
- Publication
JETP Letters, 2019, Vol 110, Issue 3, p231
- ISSN
0021-3640
- Publication type
Article
- DOI
10.1134/S0021364019150049