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- Title
Chiral NHC‐Catalyzed [4+2] Cycloadditions: Highly Diastereo/Enantioselective Access to Spiro[cyclohex‐4‐ene‐1,3′‐indoles] and DFT Calculations.
- Authors
Chen, Xiaoyu; Xia, Siqi; Hu, Xiaoru; Zhong, Guofu; Yang, Limin
- Abstract
A highly efficient NHC‐catalyzed cycloaddition of (E)‐alkenylisatins and γ‐chloroenals with a broad substrate scope has been developed to provide spiro[cyclohex‐4‐ene‐1,3′‐indole] in good yields (up to 99 % yield) with excellent diastereo‐ and enantioselectivities (up to >20 : 1 d.r. >99 % ee) under mild conditions without the use of metal and additives. Based on computational investigations, the role of the NHC on the diastereo‐ and enantioselectivity is discussed.
- Subjects
RING formation (Chemistry); METALS; ADDITIVES; INDOLE; SPIRO compounds
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 23, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202203818