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- Title
Using Aspen to Teach Chromatographic Bioprocessing: A CASE STUDY IN WEAK PARTITIONING CHROMATOGRAPHY for Biotechnology Applications.
- Authors
EVANS, STEVEN T.; XINQUN HUANG; CRAMER, STEVEN M.
- Abstract
The article explains the use of the Aspen Plus process simulators to enable students in a project to analyze liquid-phase ion exchange systems that are often unsteady-state processes. Chemical engineering students studying biotechnology and bioprocessing systems are often faced with significant purification problems. The use of weak partitioning chromatography in downstream processing of monoclonal antibodies is presented. The projects's learning objectives, goals, the Aspen Chromatography and simulation parameters are also discussed.
- Subjects
BIOTECHNOLOGY study &; teaching; CHROMATOGRAPHIC analysis; BIOCHEMICAL engineering; MONOCLONAL antibodies; ADSORPTION (Chemistry); PARTITION coefficient (Chemistry); ION exchange (Chemistry); ENGINEERING students
- Publication
CEE: Chemical Engineering Education, 2010, Vol 44, Issue 3, p198
- ISSN
0009-2479
- Publication type
Article