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- Title
Overexpression of miR-335 confers cell proliferation and tumour growth to colorectal carcinoma cells.
- Authors
Lu, Yanxia; Yang, Hui; Yuan, Li; Liu, Guobing; Zhang, Chao; Hong, Min; Liu, Yan; Zhou, Min; Chen, Fang; Li, Xuenong
- Abstract
The involvement of miR-335 in csolorectal cancer (CRC) development remains controversial. Here, we found that miR-335 was highly up-regulated in CRC specimens relative to normal mucosa, and high miR-335 expression level was markedly associated with the tumour size and differentiation of CRC. The overexpression of miR-335 in CRC cells facilitated cell proliferation in vitro and tumour growth in vivo. RASA1 was validated as a target of miR-335 that was downregulation in CRC. Forced expression of miR-335 silenced RASA1 and triggered Ras/ERK cascade in CRC. Together, miR-335-RASA1 contributes to cell growth in CRC, and elucidation of downstream pathway will provide new insights into the molecular mechanisms of CRC progression.
- Subjects
GENETICS of colon cancer; TUMOR growth; CELL proliferation; GENETIC overexpression; GENE expression
- Publication
Molecular & Cellular Biochemistry, 2016, Vol 412, Issue 1/2, p235
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-015-2630-9