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- Title
Molecular mediators of peritoneal metastasis in pancreatic cancer.
- Authors
Avula, Leela Rani; Hagerty, Brendan; Alewine, Christine
- Abstract
Pancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer diagnoses. PDA frequently metastasizes to the peritoneum, but effective treatment of peritoneal metastasis remains a clinical challenge. Despite this unmet need, understanding of the biological mechanisms that contribute to development and progression of PDA peritoneal metastasis is sparse. By contrast, a vast number of studies have investigated mechanisms of peritoneal metastasis in ovarian and gastric cancers. Here, we contrast similarities and differences between peritoneal metastasis in PDA as compared with those in gastric and ovarian cancer by outlining molecular mediators involved in each step of the peritoneal metastasis cascade. This review aims to provide mechanistic insights that could be translated into effective targeted therapies for patients with peritoneal metastasis from PDA.
- Subjects
PERITONEAL cancer; PANCREATIC cancer; METASTASIS; CANCER diagnosis; STOMACH cancer; OVARIAN cancer
- Publication
Cancer & Metastasis Reviews, 2020, Vol 39, Issue 4, p1223
- ISSN
0167-7659
- Publication type
Article
- DOI
10.1007/s10555-020-09924-4