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- Title
Synthesis and Cytotoxic Evaluation of Monocarbonyl Analogs of Curcumin as Potential Anti-Tumor Agents.
- Authors
Pan, Zheer; Chen, Chengwei; Zhou, Yeli; Xu, Feng; Xu, Yaozeng
- Abstract
Preclinical Research A series of mono ‐ carbonyl curcumin analogs with different substituents at the 4/4’ ‐ position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines using a methyl thiazolyl tetrazolium assay. Several of the curcumin analogs, especially B114, exhibited a wide ‐ spectrum of anti ‐ tumor properties in all tested cell lines, indicating their potential in as anti ‐ cancer lead compounds. Further toxicity testing in the NRK ‐ 52E kidney cell line revealed that the analogs A111, A113, and B114 had comparable or higher safety than curcumin. These data suggested that the introduction of appropriate substituents in the 4/4’ ‐ positions could be a promising approach for curcumin ‐ based drug design. Drug Dev Res 77 : 43 – 49, 2016. © 2016 Wiley Periodicals, Inc.
- Subjects
CURCUMIN; ANTINEOPLASTIC agent synthesis; CELL proliferation; ANTI-inflammatory agents; ANTIOXIDANTS; THERAPEUTICS
- Publication
Drug Development Research, 2016, Vol 77, Issue 1, p43
- ISSN
0272-4391
- Publication type
Article
- DOI
10.1002/ddr.21291