We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Image guided near-infrared spectroscopy of breast tissue in vivousing boundary element method.
- Authors
Subhadra Srinivasan; Colin M. Carpenter; Hamid R. Ghadyani; Senate J. Taka; Peter A. Kaufman; Roberta M. DiFlorio-Alexander; Wendy A. Wells; Brian W. Pogue; Keith D. Paulsen
- Abstract
We demonstrate quantitative functional imaging using image-guided near-infrared spectroscopy (IG-NIRS) implemented with the boundary element method (BEM) for reconstructing 3-D optical property estimates in breast tissue in vivo. A multimodality MRI-NIR system was used to collect measurements of light reflectance from breast tissue. The BEM was used to model light propagation in 3-D based only on surface discretization in order to reconstruct quantitative values of total hemoglobin (HbT), oxygen saturation, water, and scatter. The technique was validated in experimental measurements from heterogeneous breast-shaped phantoms with known values and applied to a total of seven subjects comprising six healthy individuals and one participant with cancer imaged at two time points during neoadjuvant chemotherapy. Using experimental measurements from a heterogeneous breast phantom, BEM for IG-NIRS produced accurate values for HbT in the inclusion with a <3 error. Healthy breast tissues showed higher HbT and water in fibroglandular tissue than in adipose tissue. In a subject with cancer, the tumor showed higher HbT compared to the background. HbT in the tumor was reduced by 9 M during treatment. We conclude that 3-D MRI-NIRS with BEM provides quantitative and functional characterization of breast tissue in vivothrough measurement of hemoglobin content. The method provides potentially complementary information to DCE-MRI for tumor characterization.
- Subjects
BREAST imaging; INFRARED spectroscopy; BOUNDARY element methods; QUANTITATIVE research; IMAGE reconstruction; MAGNETIC resonance imaging; HEMOGLOBINS
- Publication
Journal of Biomedical Optics, 2010, Vol 15, Issue 6, p061703
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3499419