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- Title
DNA Methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer.
- Authors
Belinsky, Steven A.; Schiller, Joan H.; Stidley, Christine A.
- Abstract
The article presents a study which examines the role of DNA biomarkers to assess therapy and chemoprevention for non-small cell lung cancer. It is mentioned that methylation of multiple gene promoters in sputum is strongly associated with lung cancer risk and reinforces the use of gene methylation as a biomarker in the prevention trial. The study also revealed that sputum can be used as a surrogate for tumor tissue to predict the methylation status of advanced lung cancer in cases where biopsy is not feasible. Additionally, a bar graph which shows the frequency of methylation of multiple genes in sputum obtained from lung cancer survivors and smokers is presented.
- Subjects
DNA; METHYLATION; BIOMARKERS; SPUTUM; LUNG cancer treatment; TUMOR genetics; CIGARETTE smokers; CHEMOPREVENTION; BIOPSY; PHYSIOLOGY
- Publication
Nutrition Reviews, 2008, Vol 66, pS24
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1111/j.1753-4887.2008.00061.x