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- Title
Pancreatic enzyme supplementation after gastrectomy for gastric cancer: a randomized controlled trial.
- Authors
Catarci, Marco; Berlanda, Manuele; Grassi, Giovanni Battista; Masedu, Francesco; Guadagni, Stefano
- Abstract
Background: Gastrectomy for gastric cancer is a significant cause of secondary exocrine pancreatic insufficiency. Pancreatic enzyme replacement therapy may influence nutritional status and quality of life after gastrectomy, but the pertinent clinical research to date remains controversial. A randomized controlled trial to test this hypothesis was carried out.Methods: After gastrectomy, 43 patients with gastric cancer were randomly assigned to a normal diet (Normal-d; <italic>n</italic> = 21) or to a pancreatic enzyme supplementation diet (PES-d; <italic>n</italic> = 22) and were followed up during a 12-month period, assessing nutritional status and quality of life through body mass index (BMI), instant nutritional assessment (INA) class status, serum pre-albumin (SPA) values, and GastroiIntestinal Quality of Life Index (GIQLI).Results: BMI was not significantly influenced by the type of diet; INA class status was significantly improved in the PES-d arm, particularly during the first 3 months after gastrectomy; SPA levels increased in both arms at 6 months after gastrectomy, reaching significantly higher values in the PES-d arm at 12 months. GIQLI was not significantly influenced by the type of diet throughout the follow-up period; however, this index significantly improved in the PES-d arm between the first and third month after gastrectomy.Conclusions: PES-d improves nutritional status and quality of life after gastrectomy for gastric cancer, particularly within 3 months from the operation. A larger, multicenter trial is necessary to address the potential influence of several confounding variables such as disease stage and adjuvant treatments.
- Subjects
GASTRECTOMY; PANCREATIC enzymes; QUALITY of life; BODY mass index; RANDOMIZED controlled trials
- Publication
Gastric Cancer, 2018, Vol 21, Issue 3, p542
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-017-0757-y