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- Title
Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial.
- Authors
Noormandi, Afsaneh; Khalili, Hossein; Mohammadi, Mostafa; Abdollahi, Alireza
- Abstract
Objectives: In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis. Methods: Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study. Results: Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01). Conclusions: Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes.
- Subjects
THERAPEUTIC use of magnesium; CRITICALLY ill; DIETARY supplements; LENGTH of stay in hospitals; INTENSIVE care units; INTRAVENOUS therapy; LACTATES; MAGNESIUM; MAGNESIUM sulfate; PATIENTS; PHYSIOLOGIC salines; STATISTICAL sampling; SEPSIS; RANDOMIZED controlled trials; TREATMENT effectiveness
- Publication
European Journal of Clinical Pharmacology, 2020, Vol 76, Issue 2, p175
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-019-02788-w