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- Title
Urinary Podocyte Excretion and Proteinuria in Patients Treated with Antivascular Endothelial Growth Factor Therapy for Solid Tumor Malignancies.
- Authors
Hayman, Suzanne R.; Calle, Juan C.; Jatoi, Aminah; Craici, Iasmina M.; Wagner, Steven J.; Weaver, Amy L.; Greene, Eddie L.; Grande, Joseph P.; Garovic, Vesna D.
- Abstract
Background: Urinary podocyte excretion (podocyturia) may function as a more specific marker of ongoing glomerular damage. This study sought to analyze the relationship between proteinuria and podocyturia in cancer patients treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods: Thirty-seven patients treated with anti-VEGF medications were analyzed in a single-institution, cross-sectional study. Podocyte cultures were performed on random urine collections (50-100 ml), and podocytes were identified by positive podocin staining. The corresponding urine samples were analyzed for protein and creatinine (Cr) measurements. Results: Proteinuria ≥0.5 g/g Cr was found in 30% of the patients (median, 0.12; interquartile range, 0.04-0.86), and 62% had podocyturia. There was a significant difference in the amount of podocyturia between patients with proteinuria ≥0.5 g/g Cr and those with a value <0.5 g/g Cr (median podocyturia, 1.08 cells/mg Cr, range, 0-14.55 vs. 0.03 cells/mg Cr, range, 0-1.64, respectively; p < 0.001). A statistically significant correlation was observed between the cumulative dose of bevacizumab and both proteinuria (r = 0.48, p = 0.004) and podocyturia (r = 0.34, p = 0.045) as well as between proteinuria and podocyturia (r = 0.63, p < 0.001), suggesting that these are mechanistically related. Discussion: Ongoing podocyte loss may be mechanistically related to the onset and severity of proteinuria in patients treated with anti-VEGF agents. © 2014 S. Karger AG, Basel
- Subjects
MISSISSIPPI; ENDOTHELIAL growth factors; ACADEMIC medical centers; CHI-squared test; CREATININE; HYPERTENSION; MEDICAL records; PROTEINURIA; STATISTICS; TUMORS; URINALYSIS; DATA analysis; VASCULAR endothelial growth factors; PROPORTIONAL hazards models; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PATHOLOGIC neovascularization; THERAPEUTICS
- Publication
Oncology, 2014, Vol 86, Issue 5/6, p271
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000360180