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- Title
Dynamic Instability of Central Airways and Peripheral Airspace in Rat Lungs Perfused with Cold Preservation Solutions.
- Authors
Hamakawa, H.; Sakai, H.; Takahashi, A.; Aoyama, A.; Zhang, J.; Chen, F.; Fujinaga, T.; Wada, H.; Date, H.; Bando, T.
- Abstract
Background/Aims: For lung preservation, one of two types of solutions is commonly employed: Euro-Collins (EC) or low potassium dextran glucose (LPDG). These two solutions have been compared regarding biological, morphometrical and physiological outcomes in many experiments. However, the dynamic mechanics of perfused lung are not well understood because the dynamic characteristics cannot be assessed under static conditions; hence, the primary goal of the present study was to assess this in perfused rat lungs during the preservation period, comparing EC with LPDG at 0 or 9 h at 4°C. Methods: Lung impedance was measured using a forced oscillation technique. Lung resistance and elastance values were obtained by the fast Fourier transform algorithm. The instability of central airways and heterogeneity of ventilation were estimated. Results: In the EC group, airway resistance and instability were high after perfusion, and the lung elastance was high and more heterogeneous after cold storage. In contrast, those parameters were stable in the LPDG group during cold storage. Conclusion: Such dynamic stability might facilitate the handling of lung grafts and eliminate injurious cyclic ventilation stress after reperfusion. Thus, we conclude that the impedance frequency characteristic represents a novel informative parameter for investigating lung preservation techniques. Copyright © 2011 S. Karger AG, Basel
- Subjects
GLUCOSE; REPERFUSION; CARDIOPULMONARY system; GLUCANS; LUNGS
- Publication
European Surgical Research, 2011, Vol 47, Issue 3, p159
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000330449