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- Title
A New Chloro-Containing γ-Butyrolactone from the Mangrove Endophytic Fungus Neofusicoccum parvum Y2NBKZG1016.
- Authors
Xie, Xiaoting; Xiao, Suping; Liao, Huiyi; Jiang, Qingjian; Chen, Gang; Wen, Lu
- Abstract
A new chloro-containing γ-butyrolactone derivative 1, together with eight known metabolites (2–9), were isolated from the mangrove endophytic fungus Neofusicoccum parvum Y2NBKZG1016. Its structure was identified as (4S,5S,6S,7R)-4-(3-chloro-1,2-dihydroxybutyl)-butyrolactone (1) by spectral data and chemical method. The otoprotective effects of all compounds and the ability of 1 to inhibit the release of lipopolysaccharide (LPS)-induced nitric oxide (NO) from RAW264.7 were determined.
- Subjects
ENDOPHYTIC fungi; MANGROVE plants; NITRIC oxide; LIPOPOLYSACCHARIDES; METABOLITES
- Publication
Chemistry of Natural Compounds, 2023, Vol 59, Issue 3, p424
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-023-04015-6