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- Title
090SIGNIFICANT INCREASE IN CIRCULATING TUMOUR CELLS IN PULMONARY VENOUS BLOOD DURING SURGICAL MANIPULATION IN PATIENTS WITH PRIMARY LUNG CANCER.
- Authors
Hashimoto, M.; Tanaka, F.; Yoneda, K.; Takuwa, T.; Matsumoto, S.; Kondo, N.; Okumura, Y.; Hasegawa, S.
- Abstract
Objectives: Circulating tumour cells (CTCs) are tumour cells shed from primary tumour which circulate in peripheral blood after passing through the drainage vein. This prospective study was conducted to assess changes in CTCs in the drainage pulmonary vein (PV) during lung cancer surgery.Methods: A total of 30 consecutive peripheral-type primary lung cancer patients who underwent lobectomy via thoracotomy (adenocarcinoma 73.3%; pathologic stage I 60%) were included. For each patient, 2.5 ml blood was sampled from the lobar PV of the primary tumour site before and after surgical manipulation for lobectomy. CTCs were quantitatively examined with the CellSearch system.Results: Before surgical manipulation, CTCs were detected in PV blood in the majority of patients (22/30, 73%), whereas CTCs were detected in peripheral blood in only two patients. The median number of CTCs in PV blood before manipulation (prePV-CTCs) was 4.0 (cells/2.5 ml), and there was no significant difference in prePV-CTCs according to any clinico-pathological characteristics including tumour size, progression, or histologic type. After manipulation, that is at the time of completion of lobectomy, PV-CTCs significantly increased (median postPV-CTCs 60.0, P < 0.001). Increase in postPV-CTCs was associated with microscopic lymphatic invasion. PV-CTCs significantly increased in tumours with lymphatic invasion (pre and postPV-CTCs, 4.0 and 90.5, respectively; P = 0.006), but not in tumours without lymphatic invasion (pre and postPV-CTCs, 3.5 and 7.0, respectively).Conclusions: We documented a significant increase in CTCs in drainage PV after surgical manipulation, especially in tumours with lymphatic invasion. We are awaiting survival data with 5-year follow-up, which may provide insight into the clinical significance of PV-CTCs.
- Publication
Interactive Cardiovascular & Thoracic Surgery, 2013, Vol 17, Issue suppl_2, pS91
- ISSN
1569-9293
- Publication type
Article
- DOI
10.1093/icvts/ivt372.90