We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Assessing the short- and long-term outcomes after resection of benign insulinoma.
- Authors
Tsang, Yi‐Po; Lang, Brian Hung‐Hin; Shek, Tony Wai‐Hung
- Abstract
Background Insulinoma is a rare functional pancreatic neuroendocrine tumour ( NET) believed to have an excellent long-term outcome, but few studies have solely focused on this issue after apparently curative resection. This study aimed to assess post-operative and long-term outcomes after resection of benign insulinomas. Methods From 1998 to 2013, 36 consecutive patients with insulinomas underwent surgery. Three patients had multiple endocrine neoplasia type-1 ( MEN-1). Demographics, operative findings, tumour grade (2010 World Health Organization ( WHO) NET classification), post-operative pancreatic fistula ( POPF) grade (International Study Group of Pancreatic Fistula ( ISGPF)), complications and recurrence were analysed. Results Eighteen (50%) had enucleation while the rest underwent pancreatic resection. The majority (86.1%) of insulinomas belonged to WHO NET grade G1. POPF occurred in 58.3% of patients while clinical fistula ( ISGPF grades B and C) occurred in 19.4%. One (2.8%) patient required reoperation. The occurrence of POPF was not related to type of resection or surgical approach. There was no perioperative mortality. After a mean follow-up of 83.6 months, two patients (5.7%) developed disease recurrence at 34.4 and 131.9 months after initial surgery. No patients developed distant metastasis. The 10- and 15-year disease-free rates were 95.6 and 85.4%, respectively. Conclusion POPF occurred frequently and posed a significant morbidity after resection of insulinoma. However, it occurred independently of type of resection or surgical approach. Although the immediate cure rate after resection was high (100%), long-term disease recurrence in sporadic (non- MEN-1) cases was not insignificant. Regular long-term follow-up is recommended.
- Subjects
INSULINOMA; ISLET cell tumor; NEUROENDOCRINE tumors; SURGICAL excision; TUMOR surgery
- Publication
ANZ Journal of Surgery, 2016, Vol 86, Issue 9, p706
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/ans.12891