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- Title
The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice.
- Authors
KOTLYAROVA, Anastasiya A.; PONOMAREV, Konstantin Yu.; MOROZOVA, Ekaterina A.; KORCHAGINA, Dina V.; SUSLOV, Evgeniy V.; PAVLOVA, Alla V.; TOLSTIKOVA, Tatyana G.; VOLCHO, Konstantin P.; SALAKHUTDINOV, Nariman F.
- Abstract
The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7- diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains (-)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg.
- Subjects
PHYSICAL activity; PHYSICAL fitness; AMINO group; MICE; BODY weight; BODY-weight-supported treadmill training
- Publication
Journal of Research in Pharmacy, 2020, Vol 24, Issue 2, p196
- ISSN
2630-6344
- Publication type
Article
- DOI
10.35333/jrp.2020.136