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- Title
Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine.
- Authors
Jongmok Ha; Boo Suk Na; Jong Hyeon Ahn; Minkyeong Kim; Jae Woo Kim; Jae Hyeok Lee; Jin Whan Cho; Ji Sun Kim; Jinyoung Youn
- Abstract
Background: Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder. The mainstay of treatment is managing the underlying neoplasm. However, the clinical course may be variable, and effective symptomatic management can precede the start of cancer treatment. Case report: A 63-year-old man presented with insidious onset, slowly progressive generalized chorea for 1 year, later diagnosed as anti-CV2/CRMP5 autoantibody positive paraneoplastic chorea. His chorea was markedly improved with intravenous amantadine. Discussion: In patients with anti-CV2/CRMP5 autoantibody-related chorea, sequential follow-up of brain magnetic resonance imaging reveals progression from active inflammation to atrophy. Our report highlights the efficacy of intravenous amantadine in paraneoplastic chorea.
- Subjects
AMANTADINE; CHOREA; MOVEMENT disorder treatments; DISABILITY identification; AUTOANTIBODY analysis
- Publication
Tremor & Other Hyperkinetic Movements, 2019, p1
- ISSN
2160-8288
- Publication type
Article
- DOI
10.7916/tohm.v0.701