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- Title
Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor ß.
- Authors
Rymbai, Emdormi; Sugumar, Deepa; Roy, Dhritiman; Selvaraj, Divakar
- Abstract
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERa), estrogen receptor beta (ERß), and G protein-coupled estrogen receptor 1 (GPER1 or formerly known as GPR30 or GPRx, a membranebound receptor). Overexpression of ERa and GPER1 are known to contribute to cancer, with ERa playing the most important impact. On the other hand, it is commonly acknowledged that ERß inhibits ERa activity and has anti-cancer properties. As a result, the estrogen receptors ERa and ERß are the most investigated, with ERa being recognized therapeutically as a therapeutic target for breast cancer. Unlike ERa, which must be blocked, ERß is a target that has anti-cancer properties when activated. The potential anti-cancer efficacy of ERß has been demonstrated in several pre-clinical and clinical investigations. In this review, we summarize the potential role of ERß and ERß agonists in various cancers.
- Subjects
ESTROGEN receptors; G protein coupled receptors; ANTINEOPLASTIC agents
- Publication
Pharmaceutical Sciences Asia, 2022, Vol 49, Issue 5, p408
- ISSN
2586-8195
- Publication type
Article
- DOI
10.29090/psa.2022.05.22.042