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- Title
脾酪氨酸激酶在骨重塑中的作用.
- Authors
陈艺元; 杨 倩; 吴赛璇; 张 咪; 董 明; 刘婷姣; 牛卫东
- Abstract
BACKGROUND: Spleen tyrosine kinase (Syk) was initially thought to be a hematopoietic cell-specific kinase involved in a variety of hematopoietic cell responses and immune receptor signal transmission. In recent years, studies have shown that Syk and its signaling pathway are closely related to bone remodeling, and the effect and mechanism of Syk inhibitors on bone tissue have also received extensive attention. OBJECTIVE: To review the role of Syk and its signaling pathway in bone remodeling, thereby providing ideas for bone repair and clinical treatment. METHODS: We searched the relevant articles in CNKI and PubMed databases with the keywords of “Syk, bone, osteoclast, osteoblast, inhibitor” in Chinese and English, respectively. Finally, 68 articles met the criteria for review. RESULTS AND CONCLUSION: Syk is widely expressed in non-hematopoietic cells such as osteoclasts and osteoblasts, and plays a key role in cell morphogenesis, growth, migration and survival. Bone is constantly remodeled through osteoblast-mediated bone matrix formation and mineralization as well as osteoclastmediated mineralized bone matrix degradation, which is essential for maintaining normal bone structure and function. Syk and its signaling pathway promote osteoclast differentiation and inhibit osteoblast differentiation in the process of bone remodeling. Finally, they promote the occurrence and development of bone remodeling. Syk inhibitors can improve the symptoms of bone and inflammatory diseases, especially in the aggressive and destructive stages of these diseases. Current research on Syk inhibitors is mainly focused on autoimmune and inflammation, and further exploration in bone and bone diseases is still warranted. Moreover, improving the selectivity of Syk inhibitors is also the focus of future research.
- Subjects
BONE remodeling; PROTEIN-tyrosine kinases; BONE growth; CELLULAR signal transduction; BONE diseases
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2022, Vol 26, Issue 15, p2446
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2022.605