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- Title
Signatures of natural selection in the human genome.
- Authors
Bamshad, Michael; Wooding, Stephen P.
- Abstract
During their dispersal from Africa, our ancestors were exposed to new environments and diseases. Those who were better adapted to local conditions passed on their genes, including those conferring these benefits, with greater frequency. This process of natural selection left signatures in our genome that can be used to identify genes that might underlie variation in disease resistance or drug metabolism. These signatures are, however, confounded by population history and by variation in local recombination rates. Although this complexity makes finding adaptive polymorphisms a challenge, recent discoveries are instructing us how and where to look for the signatures of selection.
- Subjects
HUMAN genome; NATURAL selection
- Publication
Nature Reviews Genetics, 2003, Vol 4, Issue 2, p99
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg999