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P4-305: Allosteric potentiation of the M1 muscarinic receptor provides unprecedented selectivity and a novel therapeutic strategy for the treatment of Alzheimer's disease
Published in:
2008
By:
- Ray, William J.;
- Seager, Matthew;
- Ma, Lei;
- Wittmann, Marion;
- Getty, Krista;
- Marlatt, Michael;
- Crouthamel, Ming-Chih;
- Wu, Guoxin;
- Sankaranarayananan, Sethu;
- Simon, Adam;
- Burno, Maryann;
- Jones, Keith;
- Graufields, Valerie Kuzmick;
- Bickel, Denise;
- Posavec, Diane;
- Cook, Jacquelynn;
- Veng, Lone;
- Kuduk, Scott;
- Sur, Cyrille;
- Shipe, William
Publication type:
Abstract
2,5-Disubstituted Pyrazolo[4,3- c]cinnolin-3-ones.
Published in:
Journal of Heterocyclic Chemistry, 2017, v. 54, n. 2, p. 1558, doi. 10.1002/jhet.2744
By:
- Beshore, Douglas C.;
- Johnson, Adam W.;
- DiPardo, Robert M.;
- Pitts, Daniel R.;
- Cofre, Victoria;
- Kuduk, Scott D.
Publication type:
Article
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.
Published in:
Frontiers in Behavioral Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnbeh.2014.00182
By:
- Tannenbaum, Pamela L.;
- Stevens, Joanne;
- Binns, Jacquelyn;
- Savitz, Alan T.;
- Garson, Susan L.;
- Fox, Steven V.;
- Coleman, Paul;
- Kuduk, Scott D.;
- Gotter, Anthony L.;
- Marino, Michael;
- Tye, Spencer J.;
- Uslaner, Jason M.;
- Winrow, Christopher J.;
- Renger, John J.
Publication type:
Article
Differential sleep-promoting effects of dual orexin receptor antagonists and GABA<sub>A</sub> receptor modulators.
Published in:
BMC Neuroscience, 2014, v. 15, n. 1, p. 109, doi. 10.1186/1471-2202-15-109
By:
- Gotter, Anthony L.;
- Garson, Susan L.;
- Stevens, Joanne;
- Munden, Regina L.;
- Fox, Steven V.;
- Tannenbaum, Pamela L.;
- Lihang Yao;
- Kuduk, Scott D.;
- McDonald, Terrence;
- Uslaner, Jason M.;
- Tye, Spencer J.;
- Coleman, Paul J.;
- Winrow, Christopher J.;
- Renger, John J.
Publication type:
Article
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
Published in:
2014
By:
- Gotter, Anthony L;
- Garson, Susan L;
- Stevens, Joanne;
- Munden, Regina L;
- Fox, Steven V;
- Tannenbaum, Pamela L;
- Yao, Lihang;
- Kuduk, Scott D;
- McDonald, Terrence;
- Uslaner, Jason M;
- Tye, Spencer J;
- Coleman, Paul J;
- Winrow, Christopher J;
- Renger, John J
Publication type:
journal article
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.
Published in:
BMC Neuroscience, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2202-14-90
By:
- Gotter, Anthony L.;
- Winrow, Christopher J.;
- Brunner, Joseph;
- Garson, Susan L.;
- Fox, Steven V.;
- Binns, Jacquelyn;
- Harrell, Charles M.;
- Donghui Cui;
- Ka Lai Yee;
- Mark Stiteler, Mark Stiteler;
- Stevens, Joanne;
- Savitz, Alan;
- Tannenbaum, Pamela L.;
- Tye, Spencer J.;
- McDonald, Terrence;
- Leon Yao;
- Kuduk, Scott D.;
- Uslaner, Jason;
- Coleman, Paul J.;
- Renger, John J.
Publication type:
Article
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.
Published in:
2013
By:
- Gotter, Anthony L;
- Winrow, Christopher J;
- Brunner, Joseph;
- Garson, Susan L;
- Fox, Steven V;
- Binns, Jacquelyn;
- Harrell, Charles M;
- Cui, Donghui;
- Yee, Ka Lai;
- Stiteler, Mark;
- Stevens, Joanne;
- Savitz, Alan;
- Tannenbaum, Pamela L;
- Tye, Spencer J;
- McDonald, Terrence;
- Yao, Leon;
- Kuduk, Scott D;
- Uslaner, Jason;
- Coleman, Paul J;
- Renger, John J
Publication type:
journal article
Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABA<sub>A</sub> Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats.
Published in:
Neuropsychopharmacology, 2013, v. 38, n. 12, p. 2401, doi. 10.1038/npp.2013.139
By:
- Fox, Steven V;
- Gotter, Anthony L;
- Tye, Spencer J;
- Garson, Susan L;
- Savitz, Alan T;
- Uslaner, Jason M;
- Brunner, Joseph I;
- Tannenbaum, Pamela L;
- McDonald, Terrence P;
- Hodgson, Robert;
- Yao, Lihang;
- Bowlby, Mark R;
- Kuduk, Scott D;
- Coleman, Paul J;
- Hargreaves, Richard;
- Winrow, Christopher J;
- Renger, John J
Publication type:
Article
Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.
Published in:
Frontiers in Neuroscience, 2013, v. 7, p. 1, doi. 10.3389/fnins.2013.00254
By:
- Ramirez, Andres D.;
- Gotter, Anthony L.;
- Fox, Steven V.;
- Tannenbaum, Pamela L.;
- Lihang Yao;
- Tye, Spencer J.;
- McDonald, Terrence;
- Brunner, Joseph;
- Garson, Susan L.;
- Reiss, Duane R.;
- Kuduk, Scott D.;
- Coleman, Paul J.;
- Uslaner, Jason M.;
- Hodgson, Robert;
- Browne, Susan E.;
- Renger, John J.;
- Winrow, Christopher J.
Publication type:
Article
The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.
Published in:
Psychopharmacology, 2013, v. 225, n. 1, p. 21, doi. 10.1007/s00213-012-2788-8
By:
- Uslaner, Jason;
- Eddins, Donnie;
- Puri, Vanita;
- Cannon, Christopher;
- Sutcliffe, Jane;
- Chew, Chan;
- Pearson, Michelle;
- Vivian, Jeffrey;
- Chang, Ronald;
- Ray, William;
- Kuduk, Scott;
- Wittmann, Marion
Publication type:
Article
DRUG DISCOVERY Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition.
Published in:
Science Translational Medicine, 2013, v. 5, n. 179, p. 1, doi. 10.1126/scitranslmed.3005213
By:
- Uslaner, Jason M.;
- Tye, Spencer J.;
- Eddins, Donnie M.;
- Xiaohai Wang;
- Fox, Steven V.;
- Savitz, Alan T.;
- Binns, Jacquelyn;
- Cannon, Christopher E.;
- Garson, Susan L.;
- Lihang Yao;
- Hodgson, Robert;
- Stevens, Joanne;
- Bowlby, Mark R.;
- Tannenbaum, Pamela L.;
- Brunner, Joseph;
- Mcdonald, Terrence P.;
- Gotter, Anthony L.;
- Kuduk, Scott D.;
- Coleman, Paul J.;
- Winrow, Christopher J.
Publication type:
Article
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey.
Published in:
Psychopharmacology, 2015, v. 232, n. 11, p. 1859, doi. 10.1007/s00213-014-3813-x
By:
- Vardigan, Joshua;
- Cannon, Christopher;
- Puri, Vanita;
- Dancho, Mandy;
- Koser, AmyJo;
- Wittmann, Marion;
- Kuduk, Scott;
- Renger, John;
- Uslaner, Jason
Publication type:
Article

Found: 12