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- Title
Dysregulation of mTOR Signaling in Neuropsychiatric Disorders: Therapeutic Implications.
- Authors
Sawicka, Kirsty; Zukin, R Suzanne
- Abstract
The article focuses on the therapeutic implications of dysregulation of PI3K-mammalian target of rapamycin (mTOR) signaling in autism spectrum disorders (ASDs). It notes that mTOR pathway are essential to synaptogenesis and are present at synapses and dysregulation of mTOR is linked to elevated cap-dependent translation and impaired synaptic plasticity which can lead to ASDs. Moreover, the findings suggest that mTOR pathway is a promising therapeutic target for the treatment of ASDs.
- Subjects
RAPAMYCIN; AUTISM spectrum disorders; NEUROPLASTICITY; SYNAPSES; NEURAL circuitry; NEUROBEHAVIORAL disorders; THERAPEUTICS
- Publication
Neuropsychopharmacology, 2012, Vol 37, Issue 1, p305
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/npp.2011.210