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- Title
Wound Modulations in Glaucoma Surgery: A Systematic Review.
- Authors
Dave, Bhoomi; Patel, Monica; Suresh, Sruthi; Ginjupalli, Mahija; Surya, Arvind; Albdour, Mohannad; Kooner, Karanjit S.
- Abstract
Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.
- Subjects
WOUND healing; GLAUCOMA; MITOMYCIN C; ENDOTHELIAL growth factors; INTRAOCULAR pressure; SURGERY
- Publication
Bioengineering (Basel), 2024, Vol 11, Issue 5, p446
- ISSN
2306-5354
- Publication type
Article
- DOI
10.3390/bioengineering11050446