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- Title
Effect of Different Exercise Training Modalities on Fasting Levels of Oxylipins and Endocannabinoids in Middle-Aged Sedentary Adults: A Randomized Controlled Trial.
- Authors
Jurado-Fasoli, Lucas; Yang, Wei; Kohler, Isabelle; Dote-Montero, Manuel; Osuna-Prieto, Francisco J.; Di, Xinyu; Hankemeier, Thomas; Krekels, Elke H.J.; Harms, Amy C.; Castillo, Manuel J.; Amaro-Gahete, Francisco J.; Martinez-Tellez, Borja
- Abstract
This study aimed to investigate the effects of different exercise training programs on fasting plasma levels of oxylipins, endocannabinoids (eCBs), and eCBs-like molecules in middle-aged sedentary adults. A 12-week randomized controlled trial was conducted using a parallel group design. Sixty-five middle-aged adults (40–65 years old) were randomly assigned to: (a) no exercise (control group), (b) concurrent training based on international physical activity recommendations (PAR group), (c) high-intensity interval training (HIIT group), and (d) HIIT together with whole-body electromyostimulation (HIIT + EMS group). Plasma levels of oxylipins, eCBs, and eCBs-like molecules were determined in plasma samples before and after the intervention using targeted lipidomics. Body composition was assessed through dual-energy X-ray absorptiometry, and dietary intake through a food frequency questionnaire and three nonconsecutive 24-hr recalls. The physical activity recommendations, HIIT, and HIIT-EMS groups showed decreased plasma levels of omega-6 and omega-3-derived oxylipins, and eCBs and eCBs-like molecules after 12 weeks (all Δ ≤ −0.12; all p <.05). Importantly, after Bonferroni post hoc corrections, the differences in plasma levels of omega-6 and omega-3 oxylipins were not statistically significant compared with the control group (all p >.05). However, after post hoc corrections, plasma levels of anandamide and oleoylethanolamide were increased in the physical activity recommendations group compared with the control group (anandamide: Δ = 0.05 vs. −0.09; oleoylethanolamide: Δ = −0.12 vs. 0.013, all p ≤.049). In conclusion, this study reports that a 12-week exercise training intervention, independent of the modality applied, does not modify fasting plasma levels of omega-6 and omega-3 oxylipins, eCBs, and eCBs-like molecules in middle-aged sedentary adults.
- Subjects
SEDENTARY lifestyles; FASTING; UNSATURATED fatty acids; BODY composition; STATISTICS; PHOTON absorptiometry; BLOOD plasma; EXERCISE physiology; NEUROTRANSMITTERS; BLOOD collection; FOOD diaries; RANDOMIZED controlled trials; PRE-tests &; post-tests; PHYSICAL activity; EXERCISE; DRUGS; QUESTIONNAIRES; STATISTICAL sampling; HIGH-intensity interval training; DATA analysis; MIDDLE age; ADULTS
- Publication
International Journal of Sport Nutrition & Exercise Metabolism, 2022, Vol 32, Issue 4, p275
- ISSN
1526-484X
- Publication type
Article
- DOI
10.1123/ijsnem.2021-0332